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In this study, the semaglutide-metformin combination showed that although no significant difference was observed in overall weight loss between the semaglutide-intensified and standard treatment groups, BMI, waist circumference, hip circumference, and body fat percentage were significantly lower in the semaglutide-intensified group

Some individuals may notice subtle changes in appetite within the first 24 to 48 hours, experiencing reduced hunger or feeling satisfied with smaller portions

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A more precise definition of the comparator groups was unavailable, and patients in those groups might have been treated with a combination of diabetes treatments (except for semaglutide for all and any other GLP-1 receptor agonist in setting B)